Your risk of developing glaucoma might increase with the onset of early menopause. According to a study at the Netherlands Ophthalmic Research Institute in Amsterdam women who go through menopause early may be at greater risk of developing. The data evaluated more than 3,000 women and found that women who went through a natural menopause before the age of 45 were more than twice as likely to be diagnosed with open-angle glaucoma as women who went through menopause at age 50 or older. The results indicate that female hormones may be protective against open-angle glaucoma. Of interest is that hormone replacement therapy (HRT) is thought to reduce fluid pressure inside the eye. Similarly, as hormone levels rise during pregnancy, fluid pressure inside the eye decreases significantly, the researchers noted. This is the first study to examine the relationship between female sex hormones, as indicated by age of menopause, and open-angle glaucoma.